A collaborative effort among Augusta University, Massachusetts General Hospital, and The Ohio State University has been launched with a $15 million grant to investigate the impact of cardiovascular and kidney disease risk factors on women. This initiative, part of the American Heart Association’s Strategically Focused Research Network (SFRN), aims to uncover why women are more susceptible to these conditions due to specific life stages and unique risk factors. By understanding biological and societal influences, researchers hope to develop targeted prevention strategies and therapies.
Cardiovascular-kidney-metabolic (CKM) syndrome represents a convergence of heart disease, kidney dysfunction, diabetes, and obesity, significantly increasing the risk of severe health outcomes. About one-third of U.S. adults exhibit at least three CKM components, such as high blood pressure or impaired kidney function. Historically underrepresented in clinical studies, women require deeper investigation into their distinct susceptibility patterns. Through innovative research projects, the SFRN seeks to bridge this knowledge gap, fostering healthier futures for all individuals.
Exploring Gender-Specific Risk Factors Across Lifespans
Research teams from Augusta University and Massachusetts General Hospital focus on how obesity and pregnancy influence CKM syndrome development in women. Their investigations aim to clarify metabolic changes over time and assess whether pregnancy-related complications can predict future cardiovascular risks. These efforts involve both experimental models and large-scale data analysis to enhance understanding of gender-specific mechanisms driving CKM progression.
At Augusta University, Jennifer Sullivan leads a comprehensive study examining lifelong obesity effects on CKM syndrome. One project investigates sex-based metabolic differences during weight gain and aging. Another explores potential adverse impacts of maternal obesity on pregnancy outcomes. Additionally, historical datasets will be analyzed to identify emerging risk factors and refine preventive measures. Meanwhile, Massachusetts General Hospital's Michael Honigberg examines placental protein production linked to maternal cardiovascular stress and evaluates postpartum interventions for hypertension management. His team also scrutinizes long-term CKM trends across women's lifespans using extensive cohort data, aiming to improve diagnostic accuracy and therapeutic efficacy.
Promoting Holistic Approaches to Women's Heart Health
The Ohio State University spearheads an initiative emphasizing personalized medicine and community engagement to combat CKM syndrome among women. By integrating pharmacological treatments, lifestyle modifications, and educational programs, researchers strive to create tailored solutions addressing diverse patient needs. This multi-faceted approach incorporates real-world evidence, behavioral science, and cultural sensitivity to maximize intervention effectiveness.
Under Joshua Joseph’s leadership, The Ohio State University develops three pioneering projects targeting CKM syndrome prevention and treatment. The DASH-CKMH project compares medication responses between genders utilizing practical clinical data. Food and Fitness WITH Medicine promotes adherence to therapeutic regimens by combining nutritional guidance, physical activity, and pharmaceutical support for older female populations. Lastly, Inspire HER fosters sustainable lifestyle improvements through supportive community networks. Together, these initiatives underscore the importance of collaboration between academic institutions and underserved communities, ensuring equitable access to advanced healthcare resources while nurturing the next generation of scientific talent.