The Los Angeles Rams and San Francisco 49ers, having emerged victorious and keeping their playoff aspirations alive, are all set to kick off Week 15 of the NFL season with an intense NFC West showdown. The 7-6 Rams find themselves a game behind the division-leading Seattle team, while the defending NFC champion 49ers are two games back. San Francisco managed to end its three-game losing streak with a win over the Bears, and the Rams secured their second consecutive win with a thrilling 44-42 victory over the Bills, which is widely regarded as one of the best games of the season. San Francisco is a 2 1/2-point favorite, slightly less than the value of home field advantage.

Where and How to Watch

The NFL Week 15 Thursday Night Football game between the Los Angeles Rams and San Francisco 49ers will take place at Levi’s Stadium in Santa Clara, California. This highly anticipated game will be streamed on Amazon Prime, ensuring that fans from all over can catch every thrilling moment.

Thursday Night Football Announcers

Al Michaels and Kirk Herbstreit will be calling the game from the Levi’s Stadium booth, providing expert commentary and analysis. Kaylee Hartung will be reporting from the sidelines, bringing fans up-close and personal with the action.

Rams vs 49ers Injury Reports

For the Los Angeles Rams, tight end Tyler Higbee is out. Cornerback Cobie Durant, defensive end Tyler Davis, receiver Jordan Whittington, tight end Davis Allen, receiver Demarcus Robinson, and offensive lineman Beaux Levensen are all listed as questionable. On the San Francisco 49ers' side, star running back Christian McCaffrey is done for the rest of the season after appearing in only four games. Backup Jordan Mason joined him on injured reserve after both went down during a Week 13 loss to the Buffalo Bills. Star defensive end Nick Bosa (hip, oblique), guard Ben Bartch (ankle), and offensive tackle Trent Williams (ankle) also did not practice on Tuesday. However, linebacker Dre Greenlaw is expected to be activated in time for his season debut.

Game Predictions

The line for the game has the 49ers as 26-point favorites with a 23-point margin of victory, and the over/under is set at 49 points. Bookies.com suggests betting on the Rams with the points against the 49ers. Bill Speros writes, "The post-Super-Bowl-hangover has claimed its latest victim in the San Francisco 49ers. The team never recovered from its 25-22 overtime loss to the Chiefs in Super Bowl 58. The 49ers were hit hard with injuries this season, as well. Christian McCaffrey is done for the season after suffering a torn PCL this past week. And his backup Jordan Mason may not see action until the 2025-26 season. Even fully staffed, opposing coordinators were able to decipher Kyle Shanahan's offense. The 49ers routed the Bears in Week 14. But does that even count? The 49ers have failed to cover in 9 straight games after a win. The Rams put up 44 points on the Bills and barely survived in a 2-point win. The trio of Matthew Stafford, Puka Nacua, and Cooper Kupp are back in top form. The Niners' 38-13 win over the Bears was more mirage than harbinger. The Rams offense can handle San Francisco's defensive front. And no one appears able to cover Kupp and Nacua these days. And stop Kyren Williams at the same time. And Brock Purdy is no Josh Allen."The Sports Betting Dime predicts that the 49ers will win with a score of 24.1 to 19.7. The site's formula indicates that the 49ers have a better chance of winning the game. ESPN gives the Rams a 39% chance of winning the NFL Week 15 game, with the remaining percentage accounting for a tie. Dimers predicts a 49ers victory with a score of 26 to 21, stating, "After extensive simulations, our model gives the Rams a win probability of 29%, while the 49ers have a win probability of 71%." Sportsnaut predicts a Rams win with a score of 27 to 21. Matt Johnson writes, "Both the Los Angeles Rams and San Francisco 49ers are coming off big wins, providing some momentum for each side for this Thursday Night Football matchup. San Francisco did get cornerback Charvarius Ward back in Week 14, giving this secondary two corners it can trust in man coverage. However, the Rams' pass rush combined with an effective run game versus a 49ers' defense that allowed 131.8 rush ypg and 4.5 ypc from Weeks 5-13 should pave the way to a win for Los Angeles."